Job Seekers

Snr Manager (Scientist II) Assay Development & Immuno Biologics and

Twitter Facebook
Apply
Location
Cambridge, MA
Salary
$120,000 - $130,000
Job Type
Direct Hire
Date
Jun 16, 2017
Job ID
2475553
Top Tier Global Pharmaceutical company expanding in their Boston HQ:
TWO POSITIONS AVAILABLE- Snr Scientist II level is Snr Manager at the organization
Competitive salary, bonus, benefits - including LTI and STI, Full relocation, bonus, stock, 401k and match and more...
If interested send resume to hbr at clinicaldynamix dot come
Senior Scientist II, Immuno Biologics -
OBJECTIVES:
 
The Immunobiologics group within Immunology Research at Company Boston is seeking an experienced Immunologist with extensive understanding of immunological pathways and mechanisms specifically related to tumor biology. The successful candidate will independently design and implement experiments to address immunological mechanisms-of-action of therapeutic molecules from concept to data interpretation. The role is a lab based research scientist who will also be responsible for participating on matrixes project teams, interfacing very closely with members of the Immuno Biologics and Immunoprofiling teams to design and optimize relevant in vivo and invitro assays to support translational efforts by bridging discovery and development projects.
   
ACCOUNTABILITIES:
 
  • Designs and develops tumor biology models, immune-oncology related models and translational research to understand mechanism of action responsible for preclinical efficacy for cancer and immunotherapy applications
  • Support drug discovery programs by providing relevant scientific and strategic input to project teams regarding relevant biomarkers and pharmacodynamics models.
  • Manages resource allocation across programs based on needs and prioritization
  • Design, execute and validate a variety of assays to understand target of interest and characterize different biologic therapeutic prototypes for IO applications
  • Develop and conduct in vitro and ex vivo mechanism of action studies to support data for efficacy studies
  • Contribute and implements new ideas and in vitro proof of concept studies to enable initiation of new discovery project concepts
  • Function effectively as a part of both functional and cross functional teams by interfacing with project teams to meet timelines and  blueprints for target product profile
  • Troubleshoot complex problems in creative and effective ways; whenever necessary and actively participates in innovation and/or optimization of established processes to ensure project goals are met
  • Spends 90% time in the laboratory, including hands on mentoring of scientists
  • Presents research findings clearly and effectively at internal and external meetings and with participants of all levels of the organization
  • Maintain familiarity with the current scientific literature in the Immunotherapy field, contribute to new target ideas and concepts
  • Supervises 1-2 junior scientists in Immuno Biologics focusing on pharmacology and cellular assays
  • May lead discovery projects
  • Maintains accurate, complete and timely data entry into laboratory notebooks
 
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:  
 
  • PhD in Immunology with a minimum of 7+ years of relevant experience, preferably in industry
  • Publications in peer reviewed journals demonstrating achievement in the above
  • Extensive hands-on experience and knowledge in a wide range of immunological assays using primary immune cells including T cells, Macrophages and dendritic cells to design new approaches for tumor killing mechanisms
  • Hands –on experience and ability to work with minimum supervision in carrying out high throughput data acquisition, analysis, storage and reporting by FACS CANTO, FACS ARIA,  ELISA, Luminex, and other flow based cytokine assays is required
  • Experience with  mammalian cell culture with best practices in tissue culture is required
  • Experience working with various mouse models for immunotherapy applications is required
  • Experience with primary human cells and tissues is strongly desired
  • Use of scientific databases and application for data management and data analysis
  • Hands on experience with automated platforms
  • Excellent written and verbal communication skills, along with the ability to work in cross-functional project teams
  • Innovative and critical thinking
  • Self-motivated, collaborative with excellent time management and organizational skills
  • Ability to advance multiple projects in a fast paced “biotech like” environment
 
TRAVEL REQUIREMENTS:
 
  • Willingness to travel to various meetings or client sites, including overnight trips.  Some international travel may be required.
  • Requires approximately 0-5% travel.
 
 
 
Scientist II, Assay Development Immunobiologics - 
OBJECTIVES:
  
The Immunobiologics group within Immunology Research at Company Boston is seeking an experienced candidate with deep and extensive understanding of biochemical and cell based assays. The successful candidate will design and implement in vitro pharmacological approaches for selecting and characterizing therapeutic modalities including antibodies and alternative antibody and biologic formats such as single domain Abs and cyclic peptides. The role is a lab based research scientist who will also be responsible for participating on matrixed project teams, interfacing with colleagues within Immunology and Oncology teams and evaluating cutting edge Immuno-oncology platforms in collaboration with external partners.  Experience in developing highthroughput assays including ELISA, FACS binding and functional assays, optimizing assay throughput and performance and analyzing high content biology data is required. Prior experience in screening of antibody and protein therapeutics candidates in inflammation including innate and adaptive immune mechanisms is strongly desired.  
  
ACCOUNTABILITIES:
 
  • Support drug discovery programs by providing relevant scientific and strategic input to project teams regarding invitro pharmacological studies
  • Manages resource allocation across programs based on needs and prioritization
  • Design and execute screening assays that enable the selection and characterization of desirable therapeutic leads against disease targets for IO applications, including development and validation of novel, cellular immunological and biochemical assays
  • Contribute and implements new ideas and in vitro proof of concept studies to enable initiation of new discovery project concepts
  • Function effectively as a part of both functional and cross functional teams by interfacing with project teams to meet timelines and  blueprints for target product profile
  • Troubleshoot complex problems in creative and effective ways; whenever necessary and actively participates in innovation and/or optimization of established processes to ensure project goals are met
  • Works effectively as a member of multi-disciplinary, cross functional teams.
  • Spends 90% time in the laboratory, including hands on mentoring of scientists.
  • Presents research findings clearly and effectively at internal and external meetings and with participants of all levels of the organization
  • May lead pipeline related projects in cross functional teams
  • Maintain familiarity with the current scientific literature in the Immunotherapy field, contribute to new target ideas and concepts
  • Maintains accurate, complete and timely data entry into laboratory notebooks
 
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:  
  • PhD in Immunology/Cell Biology with postdoctoral training and a minimum of 2+ years of relevant experience, preferably in industry
  • Publications in peer reviewed journals demonstrating achievement in the above
  • Extensive hands-on experience and knowledge in a wide range of biochemical and cell based assay development with biologics in immunology, inflammation or related areas is required
  • Hands –on experience and ability to work with minimum supervision in carrying out high throughput data acquisition, analysis, storage and reporting by FACS, ELISA, Luminex, and additional highthroughput assay formats is required
  • Experience with  mammalian cell culture with best practices in tissue culture is required
  • Experience with primary human and rodent immune cells is strongly desired
  • Use of scientific databases and application for data management and data analysis
  • Hands on experience with automated platforms
  • Excellent written and verbal communication skills, along with the ability to work in cross-functional project teams
  • Innovative and critical thinking
  • Self-motivated, collaborative with excellent time management and organizational skills
  • Ability to advance multiple projects in a fast paced “biotech like” environment